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Central serous chorioretinopathy

MedGen UID:
147591
•Concept ID:
C0730328
•
Disease or Syndrome
Synonym: Central serous chorioretinopathy after bone marrow transplantation
SNOMED CT: CSR - central serous retinopathy (312956001); Central serous choroidopathy (312956001); Central serous retinopathy (312956001); CSC - Central serous choroidopathy (312956001); Central serous chorioretinopathy (312956001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0025567
Monarch Initiative: MONDO:0018616
Orphanet: ORPHA443079

Definition

An anomaly of the retina with serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE), and associated with blurred vision, usually in one eye only and perceived typically by the patient as a dark spot in the center of the visual field with associated micropsia and metamorphopsia. Normal vision often recurs spontaneously within a few months. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral serous chorioretinopathy

Professional guidelines

PubMed

Central serous chorioretinopathy: An evidence-based treatment guideline.
Feenstra HMA, van Dijk EHC, Cheung CMG, Ohno-Matsui K, Lai TYY, Koizumi H, Larsen M, Querques G, Downes SM, Yzer S, Breazzano MP, Subhi Y, Tadayoni R, Priglinger SG, Pauleikhoff LJB, Lange CAK, Loewenstein A, Diederen RMH, Schlingemann RO, Hoyng CB, Chhablani JK, Holz FG, Sivaprasad S, Lotery AJ, Yannuzzi LA, Freund KB, Boon CJF
Prog Retin Eye Res 2024 Jul;101:101236. Epub 2024 Feb 1 doi: 10.1016/j.preteyeres.2024.101236. PMID: 38301969
Central serous chorioretinopathy: Towards an evidence-based treatment guideline.
van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO, Sivaprasad S, Querques G, Downes SM, Fauser S, Hoyng CB, Piccolino FC, Chhablani JK, Lai TYY, Lotery AJ, Larsen M, Holz FG, Freund KB, Yannuzzi LA, Boon CJF
Prog Retin Eye Res 2019 Nov;73:100770. Epub 2019 Jul 15 doi: 10.1016/j.preteyeres.2019.07.003. PMID: 31319157
Management of chronic central serous chorioretinopathy.
Hanumunthadu D, Tan ACS, Singh SR, Sahu NK, Chhablani J
Indian J Ophthalmol 2018 Dec;66(12):1704-1714. doi: 10.4103/ijo.IJO_1077_18. PMID: 30451170Free PMC Article

Recent clinical studies

Etiology

A new insight into pachychoroid diseases: Remodeling of choroidal vasculature.
Kishi S, Matsumoto H
Graefes Arch Clin Exp Ophthalmol 2022 Nov;260(11):3405-3417. Epub 2022 May 16 doi: 10.1007/s00417-022-05687-6. PMID: 35575932Free PMC Article
Should We Stop Treating Patients With Eplerenone for Chronic CSCR? Commentary on the VICI Trial.
Daugirdas SP, Bheemidi AR, Singh RP
Ophthalmic Surg Lasers Imaging Retina 2021 Jun;52(6):308-310. Epub 2021 Jun 1 doi: 10.3928/23258160-20210528-02. PMID: 34185584
Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities.
Kaye R, Chandra S, Sheth J, Boon CJF, Sivaprasad S, Lotery A
Prog Retin Eye Res 2020 Nov;79:100865. Epub 2020 May 11 doi: 10.1016/j.preteyeres.2020.100865. PMID: 32407978
Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.
Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, Jaisser F, Behar-Cohen F
Prog Retin Eye Res 2015 Sep;48:82-118. Epub 2015 May 27 doi: 10.1016/j.preteyeres.2015.05.003. PMID: 26026923
Obstructive sleep apnea and ocular disorders.
Grover DP
Curr Opin Ophthalmol 2010 Nov;21(6):454-8. doi: 10.1097/ICU.0b013e32833f00dc. PMID: 20811281

Diagnosis

Pathogenesis of central serous choroidopathy: A novel hypothesis.
Chawla R
Indian J Ophthalmol 2024 Oct 1;72(10):1387-1389. Epub 2024 Sep 27 doi: 10.4103/IJO.IJO_2188_24. PMID: 39331425
Central serous chorioretinopathy: A review.
Fung AT, Yang Y, Kam AW
Clin Exp Ophthalmol 2023 Apr;51(3):243-270. Epub 2023 Jan 30 doi: 10.1111/ceo.14201. PMID: 36597282
Should We Stop Treating Patients With Eplerenone for Chronic CSCR? Commentary on the VICI Trial.
Daugirdas SP, Bheemidi AR, Singh RP
Ophthalmic Surg Lasers Imaging Retina 2021 Jun;52(6):308-310. Epub 2021 Jun 1 doi: 10.3928/23258160-20210528-02. PMID: 34185584
Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities.
Kaye R, Chandra S, Sheth J, Boon CJF, Sivaprasad S, Lotery A
Prog Retin Eye Res 2020 Nov;79:100865. Epub 2020 May 11 doi: 10.1016/j.preteyeres.2020.100865. PMID: 32407978
Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.
Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, Jaisser F, Behar-Cohen F
Prog Retin Eye Res 2015 Sep;48:82-118. Epub 2015 May 27 doi: 10.1016/j.preteyeres.2015.05.003. PMID: 26026923

Therapy

Central serous chorioretinopathy: An evidence-based treatment guideline.
Feenstra HMA, van Dijk EHC, Cheung CMG, Ohno-Matsui K, Lai TYY, Koizumi H, Larsen M, Querques G, Downes SM, Yzer S, Breazzano MP, Subhi Y, Tadayoni R, Priglinger SG, Pauleikhoff LJB, Lange CAK, Loewenstein A, Diederen RMH, Schlingemann RO, Hoyng CB, Chhablani JK, Holz FG, Sivaprasad S, Lotery AJ, Yannuzzi LA, Freund KB, Boon CJF
Prog Retin Eye Res 2024 Jul;101:101236. Epub 2024 Feb 1 doi: 10.1016/j.preteyeres.2024.101236. PMID: 38301969
Should We Stop Treating Patients With Eplerenone for Chronic CSCR? Commentary on the VICI Trial.
Daugirdas SP, Bheemidi AR, Singh RP
Ophthalmic Surg Lasers Imaging Retina 2021 Jun;52(6):308-310. Epub 2021 Jun 1 doi: 10.3928/23258160-20210528-02. PMID: 34185584
Central serous chorioretinopathy: Towards an evidence-based treatment guideline.
van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO, Sivaprasad S, Querques G, Downes SM, Fauser S, Hoyng CB, Piccolino FC, Chhablani JK, Lai TYY, Lotery AJ, Larsen M, Holz FG, Freund KB, Yannuzzi LA, Boon CJF
Prog Retin Eye Res 2019 Nov;73:100770. Epub 2019 Jul 15 doi: 10.1016/j.preteyeres.2019.07.003. PMID: 31319157
Photosensitizers and Photodynamic Therapy: Verteporfin.
Battaglia Parodi M, La Spina C, Berchicci L, Petruzzi G, Bandello F
Dev Ophthalmol 2016;55:330-6. Epub 2015 Oct 26 doi: 10.1159/000434704. PMID: 26501167
Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.
Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, Jaisser F, Behar-Cohen F
Prog Retin Eye Res 2015 Sep;48:82-118. Epub 2015 May 27 doi: 10.1016/j.preteyeres.2015.05.003. PMID: 26026923

Prognosis

Mitogen-activated protein kinase inhibitor-associated retinopathy (MEKAR). A clinical case.
Buenasmañanas-Maeso M, Gutiérrez-Montero Ó, Reche-Sainz JA, Badillo Arcones E, Monja-Alarcón N, Toledano-Fernández N
Arch Soc Esp Oftalmol (Engl Ed) 2022 May;97(5):286-289. Epub 2022 Feb 26 doi: 10.1016/j.oftale.2022.02.006. PMID: 35526952
Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula.
van Dijk EHC, Boon CJF
Prog Retin Eye Res 2021 Sep;84:100955. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100955. PMID: 33716160
Long-term follow-up and "double layer sign" in patients affected by circumscribed choroidal hemangioma.
Murro V, Mucciolo DP, Giorgio D, Sodi A, Donati MC, Giacomelli G, Virgili G, Mazzini C, Giansanti F
Photodiagnosis Photodyn Ther 2020 Sep;31:101960. Epub 2020 Aug 17 doi: 10.1016/j.pdpdt.2020.101960. PMID: 32818639
Diagnostic and Therapeutic Challenges.
La Spina C, Modorati GM, Bandello F, Querques G, Roberts P, Fawzi AA
Retina 2018 Feb;38(2):432-437. doi: 10.1097/IAE.0000000000001586. PMID: 28272282
Central serous chorioretinopathy.
Liegl R, Ulbig MW
Ophthalmologica 2014;232(2):65-76. Epub 2014 Apr 26 doi: 10.1159/000360014. PMID: 24776999

Clinical prediction guides

Central serous chorioretinopathy: Towards an evidence-based treatment guideline.
van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO, Sivaprasad S, Querques G, Downes SM, Fauser S, Hoyng CB, Piccolino FC, Chhablani JK, Lai TYY, Lotery AJ, Larsen M, Holz FG, Freund KB, Yannuzzi LA, Boon CJF
Prog Retin Eye Res 2019 Nov;73:100770. Epub 2019 Jul 15 doi: 10.1016/j.preteyeres.2019.07.003. PMID: 31319157
Pachychoroid disease of the macula.
Stepanov A, Studnička J, Středová M, Jirásková N
Cesk Slov Oftalmol 2018 Spring;74(1):3-8. PMID: 30541290
Half-Dose Photodynamic Therapy versus High-Density Subthreshold Micropulse Laser Treatment in Patients with Chronic Central Serous Chorioretinopathy: The PLACE Trial.
van Dijk EHC, Fauser S, Breukink MB, Blanco-Garavito R, Groenewoud JMM, Keunen JEE, Peters PJH, Dijkman G, Souied EH, MacLaren RE, Querques G, Downes SM, Hoyng CB, Boon CJF
Ophthalmology 2018 Oct;125(10):1547-1555. Epub 2018 Jun 14 doi: 10.1016/j.ophtha.2018.04.021. PMID: 29776672
Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.
Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, Jaisser F, Behar-Cohen F
Prog Retin Eye Res 2015 Sep;48:82-118. Epub 2015 May 27 doi: 10.1016/j.preteyeres.2015.05.003. PMID: 26026923
Automated multi-level pathology identification techniques for abnormal retinal images using artificial neural networks.
Anitha J, Vijila CK, Selvakumar AI, Indumathy A, Jude Hemanth D
Br J Ophthalmol 2012 Feb;96(2):220-3. Epub 2011 Jun 22 doi: 10.1136/bjophthalmol-2011-300032. PMID: 21697286

Recent systematic reviews

Topical non-steroidal anti-inflammatory drugs for central serous chorioretinopathy: A systematic review and meta-analysis.
Larsson JME, Boberg-Ans LC, Vangsted A, van Dijk EHC, Grauslund J, Hajari JN, Klefter ON, Schneider M, Subhi Y
Acta Ophthalmol 2024 May;102(3):274-284. Epub 2023 Aug 8 doi: 10.1111/aos.15743. PMID: 37551858
Comparative efficacy of treatments for chronic central serous chorioretinopathy: A systematic review with network meta-analyses.
van Dijk EHC, Feenstra HMA, Bjerager J, Grauslund J, Boon CJF, Subhi Y
Acta Ophthalmol 2023 Mar;101(2):140-159. Epub 2022 Sep 30 doi: 10.1111/aos.15263. PMID: 36178171
Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis.
Chen ZJ, Lu SY, Rong SS, Ho M, Ng DS, Chen H, Gong B, Yam JC, Young AL, Brelen M, Tham CC, Pang CP, Chen LJ
Br J Ophthalmol 2022 Nov;106(11):1542-1548. Epub 2021 May 26 doi: 10.1136/bjophthalmol-2021-318953. PMID: 34039561
Spectrum of pachychoroid diseases.
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279
RISK FACTORS FOR CENTRAL SEROUS CHORIORETINOPATHY: A Systematic Review and Meta-Analysis.
Liu B, Deng T, Zhang J
Retina 2016 Jan;36(1):9-19. doi: 10.1097/IAE.0000000000000837. PMID: 26710181

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